What Is It?
A 16-amino-acid peptide — residues 176-191 of human growth hormone, plus one stabilizing tweak. Developed at Monash University in the 1990s. "AOD" stands for Anti-Obesity Drug.
How Does It Work?
HGH does many things — grows tissue, raises blood sugar, burns fat, raises IGF-1, retains water. Researchers cut HGH down to its last 16 amino acids — the part that burns fat. Threw away tissue growth. Threw away IGF-1 elevation. Threw away glucose effects. Kept only the part that targets stored fat. Activates lipolysis, upregulates beta-3 receptors, and does NOT bind the HGH receptor.
Primary Benefits (research suggests)
- Targeted fat oxidation without HGH's systemic effects
- Safety profile comparable to placebo in trials
- No glucose disruption, no IGF-1 elevation, no water retention
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- The trials failed — six trials, 900 participants.
- The 24-week, 536-person trial was terminated in 2007.
- When diet and exercise were added, the AOD signal versus placebo disappeared.
- Average loss ~2 kg over placebo in small trials — not significant in larger ones.
- Zero FDA approval.
- WADA banned.
- For research purposes only.
Research Sources
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