What Is It?
Not a peptide — a non-peptide spiropiperidine compound that mimics ghrelin. A small molecule you take as a pill. Developed by Merck in the 1990s (also known as L-163,191).
How Does It Work?
Ipamorelin is the sniper. Hexarelin is the artillery. MK-677 is the pill that borrows their uniform. Same receptor. Same target. Same end goal. But the molecule sustains the signal for hours instead of producing a clean pulse. Same key. Different keychain. Different long-term wear on the lock. GH up 97%, IGF-1 up 88% in 4 weeks. Increases appetite significantly.
Primary Benefits (research suggests)
- Oral bioavailability (no injections)
- Sustained elevated GH and IGF-1 levels
- Appetite stimulation (research)
Run the Numbers
Calculate your MK-677 dosing — capsule strength, daily totals, and protocol planning. Free, no login required.
Open the Calculator →The Honest Part
- Added 1.1 kg fat-free mass but ZERO strength gains and WORSENED insulin sensitivity (Nass 2008).
- 2011 hip-fracture trial halted at 24 weeks for heart failure increase.
- Raises fasting glucose, causes fluid retention.
- For research purposes only.
Research Sources
Verified vendors offering this compound for research purposes. Use code ROCN10 for discounts. We may earn commissions from these links.
Track MK-677 in the App
Peptide Manager Pro tracks 100+ compounds with an interactive knowledge graph, dosing calculator, protocol tracker, and AI research chat. Veteran-owned. $4.99/mo founding rate.
Get the App →