What Is It?
An actual non-steroidal SARM (Selective Androgen Receptor Modulator). Ultra-potent. Developed by Radius Health in 2010, now under development by Ellipses Pharma. Stronger androgen receptor binding than testosterone itself.
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How Does It Work?
Ostarine was the prototype. It worked. Mostly. Ligandrol was the prototype that actually delivered. RAD-140 is the prototype that overshot. Each compound is more potent than the last — and the case reports scale with the potency. Binds the androgen receptor at Ki = 7 nM (vs testosterone at 29 nM). Tissue-selective AR agonism. Oral with a long half-life.
Primary Benefits (research suggests)
- More potent at the receptor than the body's own testosterone
- Tissue-selective (targets muscle/bone over prostate)
- Oral bioavailability with long half-life
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- Chemistry explains the harm — contains TWO aryl-nitrile groups and an aromatic azo group (three known toxicophores).
- Six published liver injury cases (2020-2024), one myocarditis case, elevated liver enzymes in Phase 1 trial.
- FDA warnings issued. WADA banned.
- Counterfeit market widespread.
- For research purposes only.
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