What Is It?
A 29-amino-acid natural GHRH fragment — completely unmodified. FDA-approved in 1997 under the brand name Geref for pediatric growth hormone deficiency. The original.
How Does It Work?
Sermorelin is the original wake-up call. CJC-1295 is the same call — engineered to last longer. Both knock on the same door of the same gland. Sermorelin proved your pituitary listens. Everything since just made the conversation longer. GHRH receptor agonist with pulsatile GH release (sharp, brief), 11-12 minute half-life, and preserves natural somatostatin feedback.
Primary Benefits (research suggests)
- Natural pulsatile GH release that preserves the body's own rhythm
- Strongest compounding standing of any GH peptide due to prior FDA approval
- Proved pituitary responsiveness to GHRH stimulation
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- FDA approval was for pediatric GH deficiency — disease treatment, not anti-aging.
- Discontinued in 2008 for manufacturing difficulties (not safety — FDA confirmed in 2013).
- All adult use is off-label.
- WADA prohibited.
- For research purposes only.
Research Sources
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