What Is It?
One peptide, two formulations. Both are the same 29-amino-acid GHRH analog. The difference is a chemical add-on called DAC (Drug Affinity Complex) that changes how long the peptide stays active — and that changes everything.
How Does It Work?
Your body releases growth hormone in pulses — short bursts during sleep and after exercise. No DAC mimics that. Sharp pulse. Then quiet. Sharp pulse. Then quiet. DAC overrides it. Steady elevation. No quiet. Receptors stay activated. Convenience vs nature. That's the trade-off. DAC = convenience. No DAC = physiology.
Key Comparison
- WITH DAC — 6-8 day half-life. Sustained plateau elevation. Weekly dosing. Blunts natural GH pulsatility.
- WITHOUT DAC (Mod GRF 1-29) — ~30 minute half-life. Sharp pulse then back to baseline. Daily or twice-daily dosing. Preserves natural pulsatility and receptor sensitivity.
Run the Numbers
Calculate CJC-1295 reconstitution for both DAC and No DAC formulations — BAC water volume, syringe units. Free, no login required.
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- Most researchers prefer No DAC because it preserves the body's natural GH rhythm and receptor sensitivity.
- DAC's Phase 2 trial was halted in 2006 after a participant death (pre-existing heart condition).
- Neither formulation is FDA-approved.
- For research purposes only.
Research Sources
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