What Is It?
A 16-amino-acid peptide discovered in 2015 at USC. Encoded by your mitochondrial DNA — not your main genome. Yes, your mitochondria have their own DNA, and they use it to send messages to the rest of your body.
Everything in one place — $4.99/mo, cancel anytime.
How Does It Work?
Your mitochondria are tiny power plants inside every cell. When you exercise, they send a chemical message: "We need to upgrade." MOTS-c is that message. It's the receipt your body sends after a good workout. Activates AMPK (the metabolic master switch), improves glucose uptake and insulin sensitivity, promotes mitochondrial biogenesis, and enables stress adaptation. Levels drop with age; exercise raises them.
Primary Benefits (research suggests)
- 2021 Nature Communications: 22-month-old mice given MOTS-c doubled their running time, outrunning middle-aged controls
- Supports metabolic function and insulin sensitivity
- Promotes mitochondrial biogenesis
Run the Numbers
Calculate your MOTS-c reconstitution — BAC water volume, syringe units, and draw amounts. Free, no login required.
Open the Calculator →The Honest Part
- Most research is preclinical (mice and cell cultures).
- Some sex-specific effects observed.
- Zero FDA approval. Early-stage clinical trials only.
- Won't out-train bad metabolic habits.
- For research purposes only.
Track MOTS-c in the App
Peptide Manager Pro tracks 100+ compounds with an interactive knowledge graph, dosing calculator, protocol tracker, and AI research chat. Veteran-owned. $4.99/mo founding rate.
Get the App →